Research Into Practice

Predict Prostate

Endorsed by NICE to aid in decision making

Endorsed by East of England Cancer Alliance

Recommended by Cancer Research UK

Stratified Cancer Surveillance (STRATCANS)

Endorsed by East of England Cancer Alliance

In use to manage patients by risk in Cambridge University Hospitals NHS Trust

Cambridge Prognostic Groups

Tested and used in cohort stratification by the UK National Prostate Cancer Audit Group in 2020

Citations & Guidelines

Contributions to NICE Guidelines and Policy

Predict Prostate

Endorsed resource NICE 2019 Prostate Cancer guidelines

Imaging and biomarkers in cancer detection

Cited in NICE 2019 Prostate Cancer guidelines

Barrett Tristan, Patterson Andrew J, Koo Brendan C, Wadhwa Karan, Warren Anne Y, Doble Andrew, Gnanapragasam Vincent J, Kastner Christof, and Gallagher Ferdia A (2016) Targeted transperineal biopsy of the prostate has limited additional benefit over background cores for larger MRI-identified tumors. World journal of urology 34(4), 501-8

Gaziev G, Wadhwa K, Barrett T, Koo B C, Gallagher F A, Serrao E, Frey J, Seidenader J, Carmona L, Warren A, Gnanapragasam V, Doble A, and Kastner C (2016) Defining the learning curve for multiparametric magnetic resonance imaging (MRI) of the prostate using MRI-transrectal ultrasonography (TRUS) fusion-guided transperineal prostate biopsies as a validation tool. BJU International 117(1), 80-86

Gnanapragasam V J, Burling K, George A, Stearn S, Warren A, Barrett T, Koo B, Gallagher F A, Doble A, Kastner C, and Parker R A (2016) The Prostate Health Index adds predictive value to multi-parametric MRI in detecting significant prostate cancers in a repeat biopsy population. Scientific reports 6, 35364

Active surveillance

Cited in NICE 2019 Prostate Cancer guidelines

Thurtle D, Barrett T, Thankappan-Nair V, Koo B, Warren A, Kastner C, Saeb-Parsy K, Kimberley-Duffell J, Gnanapragasam VJ (2018). Progression and treatment rates using an active surveillance protocol incorporating image-guided baseline biopsies and multiparametric magnetic resonance imaging monitoring for men with favourable-risk prostate cancer. BJU Int. 2018 Feb 13. doi: 10.1111/bju.14166.

Salvage therapy post radiation failure

Cited in 2019 EAU – EANM -ESTRO – ESUR – SIOG Guidelines on Prostate Cancer

Y Philippou ,  RA Parker , D Volanis, VJ Gnanapragasam Comparative oncological and toxicity outcomes of salvage radical prostatectomy versus non-surgical therapies for radio-recurrent prostate cancer: A meta-regression analysis. Eur Urol Focus (2016) June:  2:2;158171

Awards & Accolades

Predict Prostate

University of Cambridge Vice Chancellors Award for Research Impact and Engagement 2019

Urology Foundation Medal 2017


Health Enterprise East – Innovation award 2016